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Sunday, February 2, 2020 | History

2 edition of Luminescent molecular rotors: novel structural probes for biological assemblies. found in the catalog.

Luminescent molecular rotors: novel structural probes for biological assemblies.

Chun En Kung

Luminescent molecular rotors: novel structural probes for biological assemblies.

  • 243 Want to read
  • 32 Currently reading

Published .
Written in English


The Physical Object
Pagination198 leaves
Number of Pages198
ID Numbers
Open LibraryOL15427956M

Laser-scanning microscopes and flow cytometers, however, require probes that are excitable at a single fixed wavelength. As electron transfer is directional, such systems have also been described by the PET principle, being described as an enhancement in PET from the receptor to the fluorophore with enhanced degree of quenching. Interaction of saxitoxin with the sensor's crown ether moiety kills its PET process towards the fluorophore and fluorescence is switched from off to on. ISBN

Fluorescent probes that detect hydrophobic interactions are currently available which are used as microviscosity and micropolarity sensors. PLoS One10 6 e We exposed Hydra to these same NPs and found that NPs tissue concentration in Hydra did not decrease after 24h in clean media unpublished data. M; Imperiali, B. Biochemistry,49,

The application of these same design principles used in chemosensing also paved the way for the development of molecular logic gates mimics MLGMs[51] [52] being first proposed using PET based fluorescent chemosensors by de Silva and co-workers in When two lattices are of similar stability, the kinetic product can be produced by slowing the rate at which individual DNA linkers dehybridize and subsequently rehybridize. Gold nanoparticle filled and core-less spherical nucleic acid structures SNAs. Analytical Chem. However, in the nanoparticle-based system, crystal structure can be tuned independent of the nanoparticle size and composition by simply adjusting the length and sequence of the attached DNA. Our focus on synthesizing novel hydroporphyrin derivatives has potential applications as activatable singlet oxygen photosensitizers to be used in PDT with possible applications in fluorescence imaging.


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Luminescent molecular rotors: novel structural probes for biological assemblies. book

Biochemistry53, This summer I have explored various synthetic pathways to produce a novel organoplatinum photonics material while generating other synthetically relevant precursors and compounds. An ideal combination of dyes for multicolor labeling would exhibit strong absorption at a coincident excitation wavelength and well-separated emission spectra Figure 7.

Most notably in the field of oncology, obtaining accurate images can be critical when excising tumor tissue while leaving healthy tissue intact. The work of Lynn Sousa in the late s, on the detection of alkali metal ions, possibly resulting in one of the first examples of the use of supramolecular chemistry in fluorescent sensing design, [35] as well as that of J.

Figure 8. We applied our new technique to the study of skeletal muscle fibers. One- and two-dimensional forms of nucleic acids e. The data revealed that although glycerol concentrations readily increased fluorescence at nm and linear increase in fluorescence intensity, albeit at lower intensity, was also observed at nm.

ChemBioChem,11, Regardless of the application, compatibility of these four elements is essential for optimizing fluorescence detection. Analytical Biochem. This tutorial describes the systems that make up a flow cytometer, and how those systems work together to collect information on individual cells as they pass through the flow cytometer's laser beam.

However, it is not known if NPs will persist in the environment, accumulate in organisms and the capacity of organisms to eliminate NPs. Molecular Probes tutorial series—Introduction to flow cytometry. Since manuscript processing time is usually determined by the reviewers' responsiveness, understanding in the case of possible delays is expected from the authors.

Hydroporphyrin Photonics Materials as Activatable Singlet Oxygen Photosensitizers

Nature Structural Biology,8, Nature Biotechnology,22, The advantages of fluorescence emission being 'switched on' from 'off' upon the recognition event enabling the chemosensors to be compared to 'beacons in the night'. Arata, T. Nature— Tetrahedron Lett. All papers will be refereed.

Scheme 1. ChemBioChem13, In addition, modern cancer treatments, such as photodynamic therapy PDTare still being extensively researched to assist in the efficiency of patient specific treatment plans. In order to be accepted, a paper must present some genuinely novel result of high interest to the scientific community.

An experimental sensor for this compound is again based on PET. Ajtai, K. Hence, a correlation can be made between luminescence intensity, quantum yield and in some cases lifetime and the analyte concentration.The purpose of the Journal of Luminescence is to provide a means of communication between scientists in different disciplines who share a common interest in the electronic excited states of molecular, ionic and covalent systems, whether crystalline, amorphous, or liquid.

May 17,  · This is keeping with the molecular rotor definition of the probe where the loss of rotation of molecule at the hydrophobic environment of the NPs surface favors loss of energy by emission processes This property is not lost in the presence of tissue extracts (S15 fraction) which makes this molecular rotor probe useful for the detection of NPs in biological sylvaindez.com by: 3.

May 30,  · The biological applications of QDs have been recently reviewed (11, 12). Here we describe a novel bioconjugation method that permits the facile generation of QD-based probes for multiplex detection of proteins in Western sylvaindez.com by: Effects of solvent polarity and solvent viscosity on the fluorescent properties of molecular rotors and related probes.

Bioorganic Chemistry33 (6), DOI: /sylvaindez.comCited by: “Chemoenzymatic Assembly of Bacterial Glycoconjugates for Site-Specific B. Current Opin. Chem. Biol.14, "Structural Analysis of WbpE from Pseudomonas aeruginosa PAO1: A Nucleotide Sugar Semisynthesis of Post-Translationally Modified Proteins and Biological Probes" Imperiali, B.: Vogel, E.

M.

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in Protein. Here we extend this strategy by covalently attaching molecular rotors to several proteins capable of assembly into fibrils, namely lysozyme, fibrinogen and amyloid-β peptide (Aβ(1–42)). We demonstrate that upon covalent attachment the molecular rotors can Cited by: 8.

Molecular sensor